Which medications in the drug class Macrolides are used in the treatment of Acute Sinusitis?

Updated: Mar 01, 2018
  • Author: Itzhak Brook, MD, MSc; Chief Editor: Michael Stuart Bronze, MD  more...
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Answer

Macrolides

Macrolide antibiotics have bacteriostatic activity and exert their antibacterial action by binding to the 50S ribosomal subunit of susceptible organisms, resulting in inhibition of protein synthesis. Macrolide antibiotics are often used in patients allergic to penicillins.

Erythromycin ethylsuccinate (E.E.S., Ery-Tab, PCE)

Erythromycin is a first-line treatment in patients allergic to penicillin. It inhibits bacterial growth, possibly by blocking dissociation of peptidyl t-RNA from ribosomes, causing RNA-dependent protein synthesis to arrest.

Clarithromycin (Biaxin)

Clarithromycin is a second-line agent. It inhibits bacterial growth, possibly by blocking dissociation of peptidyl t-RNA from ribosomes, causing RNA-dependent protein synthesis to arrest.

Azithromycin (Zithromax, Zmax)

Azithromycin, an advanced-generation macrolide, works similarly to clarithromycin but with shorter dosage time.

Erythromycin base and sulfisoxazole (Pediazole)

This agent is used for treatment of susceptible bacterial infections of upper and lower respiratory tract: in children, it is used for otitis media caused by susceptible strains of H influenzae; it is used for many other infections in patients allergic to penicillin.


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