Which medications in the drug class Penicillins are used in the treatment of Acute Sinusitis?

Updated: Mar 01, 2018
  • Author: Itzhak Brook, MD, MSc; Chief Editor: Michael Stuart Bronze, MD  more...
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Answer

Penicillins

The penicillins are bactericidal antibiotics that work against sensitive organisms at adequate concentrations and inhibit the biosynthesis of cell wall mucopeptide. The penicillins are also available in combination with agents that inactivate beta-lactamase enzymes, extending their antibiotic spectrum.

Piperacillin and Tazobactam sodium (Zosyn)

The piperacillin-tazobactam combination includes an antipseudomonal penicillin plus beta-lactamase inhibitor. It inhibits biosynthesis of cell wall mucopeptide and is effective during the stage of active multiplication.

Ticarcillin and clavulanate potassium

The ticarcillin-clavulanate combination inhibits the biosynthesis of cell wall mucopeptide and is effective during the stage of active growth. It has antipseudomonal penicillin plus a beta-lactamase inhibitor that provides coverage against most gram-positive, gram-negative, and anaerobic organisms.

Penicillin VK

Penicillin V potassium is a first-line antibiotic choice. It inhibits biosynthesis of cell wall mucopeptide. It is bactericidal against sensitive organisms when adequate concentrations are reached and most effective during the stage of active multiplication. Inadequate concentrations may produce only bacteriostatic effects.

Amoxicillin and clavulanate (Augmentin, Amoclan)

Amoxicillin-clavulanate is a second-line agent; this drug combination treats bacteria resistant to beta-lactam antibiotics.

Amoxicillin (Moxatag)

Amoxicillin is a first-line antibiotic choice. It interferes with synthesis of cell wall mucopeptides during active multiplication, resulting in bactericidal activity against susceptible bacteria.

Piperacillin

Piperacillin inhibits the biosynthesis of cell wall mucopeptides and the stage of active multiplication; it has antipseudomonal activity.


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