Which medications are effective for symptomatic treatment of acute sinusitis?

Updated: Mar 01, 2018
  • Author: Itzhak Brook, MD, MSc; Chief Editor: Michael Stuart Bronze, MD  more...
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A 15- to 21-day course of intranasal corticosteroids may reduce symptom duration when compared to placebo. [15, 45] Mometasone 200, 400, and 800 μg twice daily for 15 days is the usual regimen given, with minimal adverse effects. Systemic steroids have no proven benefit in sinusitis.

Topical ipratropium bromide 0.06% can be used to decrease rhinorrhea. Antihistamines have not been shown to be of benefit in decreasing nasal congestion; in fact, they may cause overdrying of the nasal mucosa. Mucolytics such as guaifenesin can be used to thin secretions, though they have not been definitively shown to be of benefit.

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