What are the options for second-line antibiotic therapy for acute sinusitis (sinus infection)?

Updated: Mar 01, 2018
  • Author: Itzhak Brook, MD, MSc; Chief Editor: Michael Stuart Bronze, MD  more...
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The most commonly used second-line therapies include the following:

  • Amoxicillin-clavulanate

  • Second- or third-generation cephalosporins (eg, cefuroxime, cefpodoxime, cefdinir)

  • Macrolides (ie, clarithromycin)

  • Fluoroquinolones (eg, ciprofloxacin, levofloxacin, moxifloxacin)

  • Clindamycin

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