When are second-line antibiotics indicated for acute sinusitis (sinus infection)?

Updated: Mar 01, 2018
  • Author: Itzhak Brook, MD, MSc; Chief Editor: Michael Stuart Bronze, MD  more...
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Second-line antibiotic should be considered for patients with any of the following:

  • Residence in communities with a high incidence of resistant organisms

  • Failure to respond within 48-72 hours of commencement of therapy

  • Persistence of symptoms beyond 10-14 days

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