What is the prognosis of Vibrio infections?

Updated: Jun 21, 2021
  • Author: Hoi Ho, MD; Chief Editor: Michael Stuart Bronze, MD  more...
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Answer

The prognosis is excellent in immunocompetent patients who have acute Vibrio gastroenteritis.

In patients with Vibrio wound infection or septicemia, the prognosis is very grave (12), and depends on the following:

  • Underlying medical conditions such as cirrhosis or leukemia

  • Pathogen (V vulnificus infection is associated with a 50% mortality rate.)

  • Prompt initiation of effective antibiotic therapy

  • Early fasciotomy and debridement

  • Availability of intensive monitoring and medical care for serious complications

  • Availability of reconstructive surgery and physical rehabilitation

  • Vibrio vulnificus DNA load. The median DNA copy measured by real-time PCR upon admission was 2,300 copies/mL of blood (interquartile ratio, 558 to 11,350) in patients who died of V. vulnificus sepsis was significantly higher than 316.5 copies/mL of blood (interquartile ratio, 51 to 705) in those who survived (= 0.011). [38]

  • Level of the serum tumor necrosis factor-α (TNF-α) measured on admission. The median level of the serum TNF-α in the non-survivor group of patients infected with V. vulnificus was 261.0 pg/mL, in contrast to 69.5 pg/mL in the survivor group (= 0.001). [39]


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