What are the CDC recommendations regarding immunization schedules for zoster vaccines in adults?

Updated: Feb 15, 2019
  • Author: Wayne E Anderson, DO, FAHS, FAAN; Chief Editor: Pranatharthi Haran Chandrasekar, MBBS, MD  more...
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Answer

In February 2018, the CDC approved the 2018 adult immunization schedules. Changes to the 2018 schedule regarding zoster vaccines includes the following: [10, 11]

  • Administer two doses of recombinant zoster vaccine (RZV) (Shingrix) 2-6 months apart to adults aged 50 years or older regardless of past episodes of herpes zoster or receipt of zoster vaccine live (ZVL) (Zostavax).
  • Administer two doses of RZV 2-6 months apart to adults who previously received ZVL at least 2 months after ZVL.
  • For adults aged 60 years or older, administer either RZV or ZVL (RZV is preferred).

In October 2017, the FDA approved zoster vaccine recombinant, adjuvanted (Shingrix) for the prevention of shingles in adults aged 50 years or older. The approval is based on findings from a phase III clinical trial program assessing its efficacy, safety, and immunogenicity in 38,000 patients. Data from a pooled analysis of two clinical trials demonstrated efficacy against shingles at greater than 90% across all age groups, as well as sustained efficacy over a follow-up period of 4 years. [12, 13]


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