What are the indications for nonantimicrobial agents in the treatment of prostatitis?

Updated: Jan 02, 2020
  • Author: John L Brusch, MD, FACP; Chief Editor: Michael Stuart Bronze, MD  more...
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Many nonantimicrobial agents are available for prostatitis. Narcotics, nonsteroidal anti-inflammatory drugs (NSAIDs), and tricyclic antidepressants (TCAs; eg, amitriptyline) may be needed for pain relief. Hormonal manipulation with a 5-alpha-reductase inhibitor (finasteride) may decrease glandular inflammation; lycopene, prominent in tomato sauces, may also diminish glandular swelling.

Diazepam and baclofen may decrease sphincter or perineal muscle spasm. Alpha blockers may minimize ductal reflux and dysfunctional voiding.

Because of tadalafil’s possible effect in BPH, it may be useful in preventing recurrent UTIs. [18]

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