Why is trimethoprim-sulfamethoxazole avoided in the treatment of prostatitis?

Updated: Jan 02, 2020
  • Author: John L Brusch, MD, FACP; Chief Editor: Michael Stuart Bronze, MD  more...
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The combination antimicrobial TMP-SMZ should generally be avoided. Only the TMP penetrates the prostate, and its sulfa component may be nephrotoxic. Generally, if TMP is not available because of formulary reasons, resort to quinolone or tetracycline.

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