What are potential adverse effects of Vi capsular polysaccharide (ViCPS) antigen vaccine used in the prevention of typhoid fever (enteric fever)?

Updated: Aug 19, 2019
  • Author: John L Brusch, MD, FACP; Chief Editor: Michael Stuart Bronze, MD  more...
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Answer

Adverse effects include fever, headache, erythema, and/or induration of 1 cm or greater. In a study conducted in Nepal, the ViCPS vaccine produced fewer local and systemic reactions than the control (the 23-valent pneumococcal vaccine). [73] Among school children in South Africa, ViCPS produced less erythema and induration than the control (bivalent vaccine).


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