What is the role of tinidazole in the treatment of trichomoniasis?

Updated: Jan 02, 2020
  • Author: Darvin Scott Smith, MD, MSc, DTM&H; Chief Editor: Michael Stuart Bronze, MD  more...
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Answer

Like metronidazole, tinidazole is typically given as a single-dose therapy of 2 g taken with food. Randomized clinical trials comparing single 2-g doses have shown metronidazole and tinidazole to be equally effective. [11] Cure rates range from 86%-100%. [48] Tinidazole has a longer half-life (12-14 hours) than metronidazole (6-7 hours). For resistant infections, some recommend using 2 g twice daily for 14 days. [118]

Patients on tinidazole therapy should not consume alcohol during therapy or for 72 hours after completion of the medication. [48]

Tinidazole  in Pregnancy

Tinidazole should not be used in pregnant women, as it is a pregnancy class C agent. Animal studies have demonstrated adverse effects on fetal development. [11]

In lactating women, it is recommended that breastfeeding be withheld during treatment and for 3 days after the last dose. [11]


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