What is the treatment of choice for trichomoniasis?

Updated: Jan 02, 2020
  • Author: Darvin Scott Smith, MD, MSc, DTM&H; Chief Editor: Michael Stuart Bronze, MD  more...
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Before the introduction of tinidazole, metronidazole was the treatment of choice for trichomoniasis. Metronidazole is typically administered as either a single-dose therapy taken with food or a 500-mg therapy taken twice daily with food for 7 days. Single-dose therapy is as effective as prolonged therapy, although single-dose therapy causes slightly fewer side effects and increases drug adherence. [11]

The 7-day schedule of metronidazole therapy may be more effective in treating trichomoniasis in women with HIV infection and should be considered in this population. [109] A modified 7-day schedule (400 mg 3 times a day) should be considered in breastfeeding women. [11] Studies suggest that this schedule produces a lower concentration of metronidazole in breast milk over longer periods. [119, 120]

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