What is the mechanism of action of nitroimidazoles against T vaginalis infection?

Updated: Jan 02, 2020
  • Author: Darvin Scott Smith, MD, MSc, DTM&H; Chief Editor: Michael Stuart Bronze, MD  more...
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Answer

The mechanism of action for these drugs is not completely understood. It is thought that target organisms preferentially reduce the 5-nitro group on the molecule, creating active metabolites that disrupt the helical structure of DNA. This prevents nucleic acid synthesis and eventually leads to cell death. [115]


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