How is the Xpert TV Assay used in the diagnosis of trichomoniasis?

Updated: Jan 02, 2020
  • Author: Darvin Scott Smith, MD, MSc, DTM&H; Chief Editor: Michael Stuart Bronze, MD  more...
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Answer

The Cepheid Xpert TV Assay is a DNA amplification assay developed for the Cepheid GeneXpert System, a proprietary automated cartridge platform capable of performing diagnostic tests for a wide variety of infectious agents, including T vaginalis, C trachomatis, N gonorrhoeae, influenza, group B Streptococcus, and Clostridium difficile. [90] The assay is unique among currently available nuclear amplification assays in that it is validated by the FDA for use with male urine samples. [91] An independent evaluation of the Xpert TV Assay compared the test to a combination of APTIMA TV Assay and InPouch TV broth culture. This clinical review of the Xpert TV Assay found that the test had a sensitivity ranging between 99.5% and 100% for all female samples (including swabs, urine samples, and self-collected vaginal swabs) and a specificity ranging between 99.4% and 99.9%. [91] For male urine samples, the assay had a sensitivity of 97.2% and a specificity of 99.9%. [91]

According to the manufacturer, the Xpert TV Assay has a total “hands-on” time of 1 minute, and first results are available within 40 minutes. [90]


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