Which medications in the drug class Corticosteroids are used in the treatment of Toxoplasmosis?

Updated: Mar 08, 2019
  • Author: Murat Hökelek, MD, PhD; Chief Editor: Michael Stuart Bronze, MD  more...
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Answer

Corticosteroids

These agents have anti-inflammatory properties and cause profound and varied metabolic effects. Corticosteroids modify the body's immune response to diverse stimuli. In cases in which anterior uveitis is present, topical corticosteroids are used to treat the inflammation.

Prednisone

Prednisone is used to limit inflammatory damage. The use of oral corticosteroids without antibiotic coverage may produce an immunodeficiency state that results in the rapid spread of tachyzoites and widespread retinitis. Antiparasitic agents should be stopped only after the steroids have been stopped. The steroids should never be used without antiparasitic coverage in the treatment of ocular toxoplasmosis.

Corticosteroids are probably not indicated in patients who are immunosuppressed. Some specialists wait 24-48 hours after the initiation of antibiotic therapy before starting prednisone, while others begin antibiotics and prednisone simultaneously.

Prednisolone acetate 1% (Pred Forte, Omnipred)

This agent decreases inflammation by suppressing the migration of polymorphonuclear leukocytes and reversing increased capillary permeability. The frequency of application depends on degree of ocular inflammation.


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