What is the treatment dosing regimen for toxoplasmosis during pregnancy?

Updated: Mar 08, 2019
  • Author: Murat Hökelek, MD, PhD; Chief Editor: Michael Stuart Bronze, MD  more...
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A dosing regimen for pregnant patients is as follows:

  • Spiramycin 1 g orally every 8 hours

  • If the amniotic fluid test result for T gondii is positive: 3 weeks of pyrimethamine (50 mg/day orally) and sulfadiazine (3 g/day orally in 2-3 divided doses) alternating with a 3-week course of spiramycin 1 g 3 times daily for maternal treatment OR

  • Pyrimethamine (25 mg/day orally) and sulfadiazine (4 g/day orally) divided 2 or 4 times daily until delivery (this agent may be associated with marrow suppression and pancytopenia) AND

  • Leucovorin 10-25 mg/day orally to prevent bone marrow suppression

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