What are the treatment options for toxoplasmosis during pregnancy?

Updated: Mar 08, 2019
  • Author: Murat Hökelek, MD, PhD; Chief Editor: Michael Stuart Bronze, MD  more...
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Answer

The diagnosis of acute infection is often difficult to make during pregnancy, and the administration of empiric antimicrobial therapy is discouraged.

Substantial controversy exists regarding the efficacy of treatment during pregnancy in terms of reducing the risk of fetal exposure and the subsequent development of clinical disease such as retinochoroiditis or CNS abnormalities.

Controversy also exists regarding the optimal regimen for treating maternally acquired infection. Spiramycin and pyrimethamine-sulfonamide are used, but given the infrequency of fetal infection and the asymptomatic nature of most fetal infections, treatment effects are difficult to measure. Spiramycin appears to be somewhat more easily tolerated than pyrimethamine-sulfonamide.


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