What is included in the 6-week treatment regimen for toxoplasmosis in nonpregnant patients?

Updated: Mar 08, 2019
  • Author: Murat Hökelek, MD, PhD; Chief Editor: Michael Stuart Bronze, MD  more...
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Answer

Immunocompetent, nonpregnant patients typically do not require treatment. Treatment of nonpregnant patients is described below.

The 6-week regimen is as follows:

  • Pyrimethamine (100mg loading dose orally followed by 25-50 mg/day) plus sulfadiazine (2-4 g/day divided 4 times daily) OR

  • Pyrimethamine (100-mg loading dose orally followed by 25-50 mg/day) plus clindamycin (300 mg orally 4 times daily)

  • Folinic acid (leucovorin) (10-25 mg/day) should be given to all patients to prevent hematologic toxicity of pyrimethamine

  • Trimethoprim (10 mg/kg/day) sulfamethoxazole (50 mg/kg/day) for 4 weeks


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