How is toxoplasmosis transmitted to lab workers?

Updated: Mar 08, 2019
  • Author: Murat Hökelek, MD, PhD; Chief Editor: Michael Stuart Bronze, MD  more...
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Answer

Laboratory workers can become infected via ingestion of sporulated T gondii oocysts from feline fecal specimens or via skin or mucosal contact with either tachyzoites or bradyzoites in human or animal tissue or culture. Laboratories should have established protocols for handling specimens that contain viable T gondii and for responding to laboratory accidents.

Currently, the only effective vaccine against toxoplasmosis is Toxovax, which contains a live attenuated S48 strain and controls congenital infection in sheep. Toxovax decreases the abortion rate but does not eradicate T gondii completely. Nevertheless, it is expensive and may be changed into a pathogenic form; for this reason, it is not appropriate for human use. Unfortunately, no licensed vaccine is yet available for humans. [55]


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