Which physical findings suggest toxoplasmosis in patients with AIDS?

Updated: Mar 08, 2019
  • Author: Murat Hökelek, MD, PhD; Chief Editor: Michael Stuart Bronze, MD  more...
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Answer

Host immune function plays an important role in the pathogenicity of toxoplasmosis. Symptoms depend largely on the organ system and tissue involved and may be gradual in onset over a few weeks. They include the following:

  • CNS toxoplasmosis - Seizure, mental status change, focal motor deficits, cranial nerve disturbances, sensory disturbances, cerebellar abnormalities, movement disorders, neuropsychiatric findings

  • Retinochoroiditis (similar to that seen in immunocompetent individuals)

  • Pneumonitis - More common in patients who have undergone bone marrow transplantation and in patients with AIDS; nonproductive cough, blood-tinged sputum, hypoxia (symptoms indistinguishable from P [carinii] jiroveci)

  • Septic shock–like presentation


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