What are the signs and symptoms of acute toxoplasmosis in immunocompromised hosts?

Updated: Mar 08, 2019
  • Author: Murat Hökelek, MD, PhD; Chief Editor: Michael Stuart Bronze, MD  more...
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Answer

The disease in these patients may be newly acquired or a reactivation. It may be characterized as follows:

  • CNS toxoplasmosis occurs in 50% of patients - Seizure, dysequilibrium, cranial nerve deficits, altered mental status, focal neurologic deficits, headache

  • Patients may have encephalitis, meningoencephalitis, or mass lesions

  • Hemiparesis and seizures have been reported

  • Patients may report visual changes

  • They may have signs and symptoms similar to those observed in immunocompetent hosts.

  • Patients may have flulike symptoms and lymphadenopathy

  • Myocarditis and pneumonitis are reported.

  • Toxoplasmic pneumonitis can occur - Typical symptoms of a pulmonary infection, mirroring in particular P (carinii) jiroveci, including nonproductive cough, dyspnea, chest discomfort, and fever

Symptoms associated with reactivation toxoplasmosis are dependent on the tissue or organ affected.


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