What is the pathogenesis of toxoplasmosis in patients with HIV infection?

Updated: Mar 08, 2019
  • Author: Murat Hökelek, MD, PhD; Chief Editor: Michael Stuart Bronze, MD  more...
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Answer

Most cases of toxoplasmosis in immunocompromised patients are a consequence of latent infection and reactivation. In patients with AIDS, T gondii tissue cysts can reactivate with CD4 counts of less than 200 cells/μL; with counts of less than 100 cells/μL, clinical disease becomes more likely. [19] Without adequate prophylaxis or restoration of immune function, patients with CD4 counts of less than 100 cells/μL who are T gondii IgG-antibody positive have a 30% risk of eventually developing reactivation disease. [20]


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