Which medications in the drug class Crystalloids are used in the treatment of Toxic Epidermal Necrolysis (TEN)?

Updated: Jul 01, 2021
  • Author: Samantha P Jellinek-Cohen, PharmD, BCPS (AQ-ID); Chief Editor: Michael Stuart Bronze, MD  more...
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Answer

Crystalloids

Fluid resuscitation is critical in TEN. In cases of acute skin failure, insensible losses may be enormous, and repletion of water loss is essential.

Isotonic sodium chloride 0.9%

Patients with TEN are at serious risk of dehydration, which may complicate their condition. For example, water losses in a hypercatabolic state result in hypoalbuminemia and reduced renal perfusion. This leads to acute renal failure; therefore, maintaining intravascular volume is paramount. The rate of intravenous repletion should be titrated based on urine output or central venous pressure.


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