Which medications in the drug class Anticoagulants are used in the treatment of Toxic Epidermal Necrolysis (TEN)?

Updated: Jul 01, 2021
  • Author: Samantha P Jellinek-Cohen, PharmD, BCPS (AQ-ID); Chief Editor: Michael Stuart Bronze, MD  more...
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Heparin is indicated for prophylaxis of thromboembolic events. Patients with TEN remain nonambulatory until skin begins to heal, and until that time, anticoagulant therapy is imperative.


Heparin augments activity of antithrombin III and prevents conversion of fibrinogen to fibrin. It does not actively lyse thrombus but is able to inhibit further thrombogenesis. Heparin prevents reaccumulation of clot after spontaneous fibrinolysis. It is indicated for the prevention of thromboembolic events.

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