Which medications in the drug class Analgesics are used in the treatment of Toxic Epidermal Necrolysis (TEN)?

Updated: Jul 01, 2021
  • Author: Samantha P Jellinek-Cohen, PharmD, BCPS (AQ-ID); Chief Editor: Michael Stuart Bronze, MD  more...
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Opiate analgesics are important to alleviate pain and anxiety associated with TEN. Much like treatment of a second-degree burn, the pain must not be ignored.

Morphine sulfate (Duramorph, Astramorph, MS Contin)

Morphine is the drug of choice for pain in patients with TEN. In case of allergy or intolerability, fentanyl may be used.

Fentanyl Citrate ( Fentora, Abastral, Duragesic)

A synthetic opioid analgesic that is primarily a mu receptor agonist, fentanyl is 50-100 times more potent than morphine. It has short duration of action (1-2 h) and minimal cardiovascular effects, such as hypotension. Respiratory depression is uncommon, but this effect lasts longer than its analgesic effect. Fentanyl is frequently used in patient-controlled analgesia for relief of pain. Unlike morphine, fentanyl is not commonly associated with histamine release.

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