What are the benefits of anti-tumor necrosis factor–alpha (TNF-alpha) inhibitors in the treatment of toxic epidermal necrolysis (TEN)?

Updated: Jul 01, 2021
  • Author: Samantha P Jellinek-Cohen, PharmD, BCPS (AQ-ID); Chief Editor: Michael Stuart Bronze, MD  more...
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Answer

Anti–TNF-α treatment has been reported to rapidly resolve skin lesions due to TEN. TNF-α is strongly expressed in keratinocytes and macrophages of lesional skin, and high concentrations are found in cutaneous blister fluid.


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