What are the treatment guidelines for toxic epidermal necrolysis (TEN)?

Updated: Jul 01, 2021
  • Author: Samantha P Jellinek-Cohen, PharmD, BCPS (AQ-ID); Chief Editor: Michael Stuart Bronze, MD  more...
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No controlled prospective treatment studies or generally accepted guidelines exist. In 1991, Avakian and colleagues published the University of Florida treatment protocol for toxic epidermal necrolysis. [43] In 2007, these guidelines were revised by Fromowitz and colleagues. [44] The guidelines are as follows:

Monitor fluids and electrolytes. Administer fluids and titrate based on central venous pressure and urine output; on average, 3-4 L are needed in patients with 50% of the body surface area affected.

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