How is erythema multiforme major (EMM) differentiated from toxic epidermal necrolysis (TEN)?

Updated: Jul 01, 2021
  • Author: Samantha P Jellinek-Cohen, PharmD, BCPS (AQ-ID); Chief Editor: Michael Stuart Bronze, MD  more...
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Answer

EMM is characterized by typical target lesions (at least 3 concentric rings) with or without blister formation in a symmetric, predominantly acral distribution. In contrast, the skin lesions of SJS and TEN are predominately central (trunk and face), consisting of blisters that arise on erythematous or purpuric macules and involve 2 or more mucosal surfaces.


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