Which skin exam findings are characteristic of toxic epidermal necrolysis (TEN)?

Updated: Jul 01, 2021
  • Author: Samantha P Jellinek-Cohen, PharmD, BCPS (AQ-ID); Chief Editor: Michael Stuart Bronze, MD  more...
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Answer

Skin lesions begin as painful/burning, warm, erythematous, morbilliform macules that are initially discrete. They begin symmetrically on the face and thorax before spreading to the entire body. The skin lesions coalesce and fill with fluid-producing large, flaccid blisters. The epidermis sloughs in sheets, leaving a characteristic moist, denuded dermis. Conjunctivitis and denudation and erosions of other mucous membranes precede epidermal necrolysis.

Epidermal sloughing in toxic epidermal necrolysis Epidermal sloughing in toxic epidermal necrolysis (TEN).
Toxic epidermal necrolysis (TEN) ulcer in great to Toxic epidermal necrolysis (TEN) ulcer in great toe (initial infection).

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