What are the prodromal signs and symptoms of toxic epidermal necrolysis (TEN)?

Updated: Jul 01, 2021
  • Author: Samantha P Jellinek-Cohen, PharmD, BCPS (AQ-ID); Chief Editor: Michael Stuart Bronze, MD  more...
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Patients with toxic epidermal necrolysis (TEN) may describe an influenzalike prodrome characterized by the following:

  • Malaise

  • Rash

  • Fever

  • Cough

  • Arthralgia

  • Myalgia

  • Rhinitis

  • Headache

  • Anorexia

  • Nausea and vomiting, with or without diarrhea

Other prodromal signs and symptoms include conjunctivitis (32%), pharyngitis (25%), and pruritus (28%). The prodrome typically lasts from 1 day to as long as 3 weeks.

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