What causes widespread epidermolysis and blistering in toxic epidermal necrolysis (TEN)?

Updated: Jul 01, 2021
  • Author: Samantha P Jellinek-Cohen, PharmD, BCPS (AQ-ID); Chief Editor: Michael Stuart Bronze, MD  more...
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Answer

The widespread epidermolysis and blistering of TEN results from keratinocyte apoptosis—an organized series of biochemical reactions leading to cell changes and cell death. [7] However, the number of inflammatory T cells in the skin of patients with TEN is variable and perhaps too low to explain the widespread destruction. [8]


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