What is the goal of medication in the treatment of strongyloidiasis?

Updated: Jun 20, 2019
  • Author: Pranatharthi Haran Chandrasekar, MBBS, MD; Chief Editor: Michael Stuart Bronze, MD  more...
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Answer

The goals of pharmacotherapy in strongyloidiasis are to eradicate the infection, reduce morbidity, and prevent complications.

Several anthelmintic drugs are available for established infection. Thiabendazole was a therapeutic option for strongyloidiasis but has been discontinued. Albendazole and mebendazole have been used in patients with Strongyloides stercoralis infection, but results have varied. Ivermectin has been shown to be more effective than albendazole.

Patients with hyperinfection and disseminated disease should be treated with ivermectin. For those too sick to tolerate or absorb oral (PO) ivermectin, rectal (PR) or subcutaneous (SC) dosing may be effective. [75] In these patients, ivermectin should be administered daily until symptoms have resolved and larvae have not been detected for at least 2 weeks.


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