What is the role of antibiotic therapy and supportive care in the treatment of strongyloidiasis?

Updated: Jun 20, 2019
  • Author: Pranatharthi Haran Chandrasekar, MBBS, MD; Chief Editor: Michael Stuart Bronze, MD  more...
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Answer

Provide antibiotic therapy directed toward enteric pathogens if bacteremia or meningitis is present or suggested; treat such bacterial complications for 2-4 weeks with antibiotics according to the results of in vitro testing against the bacterial isolate(s).

Provide supportive treatment as indicated (eg, intravenous fluids if volume depletion, blood transfusion if gastrointestinal or alveolar hemorrhage, mechanical ventilation if respiratory failure). Symptomatic treatment should be initiated. Pruritic dermatologic manifestations should be treated with antihistamines. Inhaled beta-agonists may improve wheezing; steroids should be avoided as they will worsen the infection. The use of leukotriene synthesis inhibitors for wheezing may also worsen infection, because leukotrienes are shown to play a potential role in the immunity against Strongyloides infection.


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