What are the assay findings in strongyloidiasis?

Updated: Jun 20, 2019
  • Author: Pranatharthi Haran Chandrasekar, MBBS, MD; Chief Editor: Michael Stuart Bronze, MD  more...
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Answer

A study of an anti-Strongyloides IgG enzyme immunoassay (EIA) showed it to be rapid and easy to perform, and it may be a good option when a parasitologic stool examination is negative, as well as in immunosuppressed patients. [58]

S stercoralis–specific recombinant antigens such as 31-kDa recombinant antigen (NIE) and S stercoralis immunoreactive antigen (SsIR) can help overcome the limitations of antibody-based assays. [59] A luciferase immunoprecipitation systems assay has been described, which may eventually prove to be more accurate than existing ELISA testing. [60, 61]

Polymerase chain reaction (PCR) on stool specimens has also been described but is currently under investigation. [61, 62, 63] A 2018 systematic review found that nucleic acid amplification tests have a sensitivity of 71% and a specificity of 93%. [64]

In a study that evaluated gelatin particle agglutination test (GPAT) and ELISA results in endemic regions of Thailand, the GPAT was judged to be more practical for screening for strongyloidiasis than the conventional ELISA. [65]


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