Which immunodiagnostic assays are used in the workup of strongyloidiasis?

Updated: Jun 20, 2019
  • Author: Pranatharthi Haran Chandrasekar, MBBS, MD; Chief Editor: Michael Stuart Bronze, MD  more...
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Serodiagnosis can be helpful but is not readily available, and false-negative results may occur. Several immunodiagnostic assays have been developed, including skin testing with larval extracts, indirect immunofluorescence using killed larvae, filarial complement fixation testing, indirect agglutination testing, radioallergosorbent testing for specific immunoglobulin E (IgE) (total serum IgE level is usually elevated), gelatin particle indirect agglutination (GPIA), Western blot analysis, enzyme-linked immunosorbent assay (ELISA) for IgG antibodies and immunoprecipitation technique combined with a recombinant antigen. [53]

Often, establishing a diagnosis and confirming a cure of strongyloidiasis is difficult. Strongyloides -specific antibody levels may be used for serologic follow-up for strongyloidiasis. [54] They may indicate reversion to negative serostatus after successful ivermectin therapy, which is frequent.

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