What is the pathophysiology of stage 2 of the Strongyloides stercoralis life cycle in strongyloidiasis?

Updated: Jun 20, 2019
  • Author: Pranatharthi Haran Chandrasekar, MBBS, MD; Chief Editor: Michael Stuart Bronze, MD  more...
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Answer

Migration of infective larvae traditionally has been believed to occur via the lymphatic vessels and venules. These larvae reach the pulmonary circulation, where, once in the pulmonary capillaries, the larvae produce hemorrhages, which form the avenue of penetration into the alveolar space. An inflammatory response associated with eosinophilic infiltration follows, and the sequence of events that occurs in the lungs results in pneumonitis. The larvae migrate up the pulmonary tree, where they are swallowed (see the following image) and finally enter the intestine.

Second stage, life cycle of Strongyloides stercora Second stage, life cycle of Strongyloides stercoralis. Illustration by Tessa Kalman.

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