What are the IDSA guidelines for the treatment of group A streptococcal (GAS) infections?

Updated: Apr 08, 2021
  • Author: Zartash Zafar Khan, MD, FACP; Chief Editor: Pranatharthi Haran Chandrasekar, MBBS, MD  more...
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Treatment guidelines are as follows:

  • Penicillin or amoxicillin is the recommended drug of choice.
  • For penicillin-allergic patients, first-generation cephalosporin (for those not anaphylactically sensitive), clindamycin, clarithromycin, or azithromycin
  • As an adjunct to antibiotic therapy, acetaminophen or an NSAID should be considered for treatment of moderate to severe symptoms or control of high fever
  • Aspirin should be avoided in children
  • Corticosteroids are not recommended as adjunctive therapy  
  • Tonsillectomy solely to reduce the frequency of GAS pharyngitis is not recommended

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