How are group A streptococcal (GAS) infections prevented?

Updated: Sep 07, 2018
  • Author: Zartash Zafar Khan, MD, FACP; Chief Editor: Pranatharthi Haran Chandrasekar, MBBS, MD  more...
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Answer

Apart from rheumatic fever prophylaxis and the prevention of intrafamily spread, few strategies are available to prevent streptococcal infection. [33]

A streptococcal vaccine could be a promising tool for disease prevention, but an effective vaccine would have to provide protection from multiple serotypes. Furthermore, theoretical concern that vaccine-induced antibodies could injure host tissue and precipitate rheumatic fever is recognized.

Multivalent vaccines that contain multiple M-protein peptide epitopes have been engineered and show efficacy in animal models but have not yet entered clinical trials. [34] However, several vaccine candidates against GAS infection are in varying stages of preclinical and clinical development, and the hope is that one of these vaccines will reach licensure within the next decade. [35] Only the multivalent N-terminal vaccine has entered clinical trials over the last 30 years.


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