Which antigen tests appear most promising for in diagnosing schistosomiasis (bilharzia)?

Updated: Sep 20, 2018
  • Author: Shadab Hussain Ahmed, MD, AAHIVS, FACP, FIDSA; Chief Editor: Michael Stuart Bronze, MD  more...
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Answer

The 2 proteoglycan, gut-associated antigens that appear most promising are circulating anodic antigen (CAA) and circulating cathodic antigen (CCA). These antigens can be found in urine or serum. [47]

Studies are underway to evaluate the sensitivity and specificity of these investigational antigen tests. A reagent strip using monoclonal antibodies to detect somatic schistosome antigens in urine has a sensitivity of more than 85% and is suitable for use in the field. [48]


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