What is the role of serologic testing in the diagnosis of schistosomiasis (bilharzia)?

Updated: Sep 20, 2018
  • Author: Shadab Hussain Ahmed, MD, AAHIVS, FACP, FIDSA; Chief Editor: Michael Stuart Bronze, MD  more...
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Answer

Serologic findings can be used to reach a diagnosis in a patient from a nonendemic area, because a negative antibody test result would be expected.

Detection of antibodies to S mansoni, S haematobium, and S japonicum adult worm microsomal antigens (ie, mansoni adult worm microsomal antigen [MAMA], haematobium adult worm microsomal antigen [HAMA], japonicum adult worm microsomal antigen [JAMA]) has been reported to be highly specific for all 3 species when the Falcon assay screening test (FAST), enzyme-linked immunoassay (ELISA), and immunoblot assays have been used. [45]


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