What is the role of ectopic egg deposition in the pathogenesis of schistosomiasis (bilharzia)?

Updated: Sep 20, 2018
  • Author: Shadab Hussain Ahmed, MD, AAHIVS, FACP, FIDSA; Chief Editor: Michael Stuart Bronze, MD  more...
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Answer

Ectopic egg deposition can lead to additional clinical syndromes, including involvement of skin, lungs, brain, muscles, adrenal glands, genitalia, and eyes. CNS involvement can result in transverse myelitis (best described for S haematobium and S mansoni) and/or cerebral disease (most common with S japonicum infection). Local tissue invasion of eggs brings about the release of toxins and enzymes and provokes a TH-2–mediated immune response. [22]


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