What should be monitored during antibiotic therapy for Proteus infections?

Updated: Mar 03, 2020
  • Author: Shirin A Mazumder, MD, FIDSA; Chief Editor: Michael Stuart Bronze, MD  more...
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Answer

Antibiotic therapy requires constant observation for signs of overgrowth of nonsusceptible organisms, including fungi. Overgrowth more usually occurs in the setting of chronic UTIs or in patients with indwelling catheters than in uncomplicated UTIs. If superinfection occurs (usually involving Aerobacter, Pseudomonas, or Candida organisms), discontinue the offending drug and/or institute appropriate therapy. As with any potent agent, it is advisable to periodically check for organ system dysfunction during prolonged therapy, to include the renal, hepatic, and hematopoietic systems. This measure is particularly important in premature infants, neonates, and other infants.


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