Which medications in the drug class Antitubercular Agents are used in the treatment of Pott Disease (Tuberculous [TB] Spondylitis)?

Updated: Aug 08, 2019
  • Author: Jose A Hidalgo, MD; Chief Editor: John L Brusch, MD, FACP  more...
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Answer

Antitubercular Agents

These agents inhibit the growth and proliferation of the causative organism.

Isoniazid

Isoniazid is highly active against Mycobacterium tuberculosis. It has good gastrointestinal (GI) absorption and penetrates well into all body fluids and cavities.

Rifampin (Rifadin)

Rifampin is for use in combination with at least 1 other antituberculous drug. It inhibits deoxyribonucleic acid (DNA) ̶ dependent bacterial (but not mammalian) ribonucleic acid (RNA) polymerase. Cross resistance may occur.

Pyrazinamide

Pyrazinamide is bactericidal against M tuberculosis in an acid environment (macrophages). It has good absorption from the GI tract and penetrates well into most tissues, including the cerebrospinal fluid (CSF).

Ethambutol (Myambutol)

Ethambutol has bacteriostatic activity against M tuberculosis. The drug has good GI absorption. CSF concentrations remain low, even in the presence of meningeal inflammation.

Streptomycin

Streptomycin is bactericidal in an alkaline environment. Because it is not absorbed from the GI tract, the drug must be administered parenterally. Streptomycin exerts action mainly on extracellular tubercle bacilli. Only about 10% of the drug penetrates cells that harbor organisms. Streptomycin enters the CSF only in the presence of meningeal inflammation. Excretion is almost entirely renal.


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