What are the AUA treatment guidelines for symptomatic, metastatic castration-resistant prostate cancer (CRPC) with good performance status and prior docetaxel chemotherapy?

Updated: Jul 31, 2017
  • Author: Bagi RP Jana, MD; more...
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Answer

Answer

Recommendations are as follows:

  • Abiraterone plus prednisone, cabazitaxel, or enzalutamide

  • If the patient received abiraterone plus prednisone prior to docetaxel chemotherapy, offer cabazitaxel or enzalutamide

  • Ketoconazole plus steroid if abiraterone plus prednisone, cabazitaxel, or enzalutamide is unavailable

  • Re-treatment with docetaxel for patients who were benefiting from but discontinued treatment with docetaxel because of reversible adverse effects

  • Radium-223 to patients with symptoms from bony metastases and without known visceral disease


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