Which medications in the drug class Vaccines are used in the treatment of Pneumococcal Infections (Streptococcus pneumoniae)?

Updated: Jun 08, 2020
  • Author: ; Chief Editor: John L Brusch, MD, FACP  more...
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Answer

Vaccines

Pneumococcal vaccines are recommended by the CDC as part of routine prophylaxis in young children (aged < 5 y) and adults aged 65 y or older. These vaccines are also recommended for individuals who are immunocompromised (eg, HIV, cancer, renal disease) or have functional or anatomic asplenia, cerebrospinal fluid leaks, or cochlear implants. [90, 91, 93]

Pneumococcal vaccine 13-valent (Prevnar 13)

Indicated for routine vaccination in infants. Also for high-risk children and adults who are immunocompromised (eg, HIV, cancer, renal disease) or have functional or anatomic asplenia, cerebrospinal fluid leaks, or cochlear implants.

Capsular polysaccharide vaccine against 13 strains of S pneumoniae, conjugated to nontoxic diphtheria protein, including serotypes 1, 3, 4, 5, 6A, 6B, 7F, 9V, 14, 18C, 19A, 19F, and 23F.

Pneumococcal vaccine polyvalent (Pneumovax 23)

Indicated as routine vaccination for adults aged 65 years or older. Also indicated for high-risk adults and children who have chronic heart or lung disease, are immunocompromised, or have functional or anatomic asplenia, cerebrospinal fluid leaks, or cochlear implants.

S pneumoniae capsular antigens stimulate active immune response, resulting in production of endogenously produced antibodies. The 23 serotypes contained in the vaccine include : 1, 2, 3, 4, 5, 6B, 7F, 8, 9N, 9V, 10A, 11A, 12F, 14, 15B, 17F, 18C, 19F, 19A, 20, 22F, 23F, and 33F.


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