How are hospitalized patients with pneumococcal meningitis monitored during treatment?

Updated: Jun 08, 2020
  • Author: Eduardo Sanchez, MD; Chief Editor: John L Brusch, MD, FACP  more...
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A repeat lumbar puncture should be considered after 48 hours of therapy in the following circumstances:

  • Patients whose isolates are not susceptible to penicillin based on oxacillin disc diffusion testing or MIC testing without pending results of cefotaxime and/or ceftriaxone susceptibilities
  • Patients whose condition has worsened or has not improved
  • Patients who received steroid therapy (which could alter the ability to observe clinical improvement/worsening)

Patients with pneumococcal meningitis should receive the entire course of antibiotic therapy parenterally.

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