When is revaccination against pneumococcal infections indicated?

Updated: Jun 08, 2020
  • Author: Eduardo Sanchez, MD; Chief Editor: John L Brusch, MD, FACP  more...
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The duration of protection is probably 5-10 years but may vary widely. Revaccination is recommended in certain populations, including the following:

  • Five years after initial immunization in children aged 2 years or older at high risk for pneumococcal infection or in whom antibody titers are highly likely to rapidly decline, including those with functional or anatomic asplenia, sickle cell disease, or immunosuppression. All other children with underlying medical conditions should receive 1 dose of PPSV23.

  • Persons aged 65 years or older who are at high risk for disease or rapid antibody decline, including those with asplenia, HIV, leukemia, lymphoma, Hodgkin disease, multiple myeloma, malignancy, renal disease, or organ/marrow transplant or those on immunosuppressive therapies

A study showed that, in elderly patients with chronic illness, dual vaccination with pneumococcal polysaccharide vaccine and influenza vaccine led to decreased complications related to respiratory, cardiovascular, and cerebrovascular diseases. [95] A reduction in hospitalizations, critical illness, and death was also noted in these patients.

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