Which defective antibody formations increase the risk for pneumococcal infection?

Updated: Jun 08, 2020
  • Author: Eduardo Sanchez, MD; Chief Editor: John L Brusch, MD, FACP  more...
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Defective antibody formation

  • Primary

    • Congenital agammaglobulinemia

    • Common variable hypogammaglobulinemia

    • Selective immunoglobulin G (IgG) subclass deficiency

  • Secondary

    • Lymphoma

    • Chronic lymphocytic leukemia

    • Multiple myeloma

    • HIV infection

Defective complement (primary or secondary): Absent or decreased amounts of C1, C2, C3, or C4

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