Which medications in the drug class Anthelmintics are used in the treatment of Pinworm (Enterobiasis)?

Updated: Nov 21, 2018
  • Author: Sun Huh, MD, PhD; Chief Editor: Michael Stuart Bronze, MD  more...
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Answer

Anthelmintics

Parasite biochemical pathways are sufficiently different from the human host to allow selective interference by chemotherapeutic agents in relatively small doses.

Mebendazole

Mebendazole causes worm death by selectively and irreversibly blocking uptake of glucose and other nutrients in susceptible adult intestine where helminths dwell.

Pyrantel pamoate (Reese's Pinworm Medicine, Pin-X)

Pyrantel pamoate is a depolarizing neuromuscular blocking agent. It inhibits cholinesterases, resulting in spastic paralysis of the worm.

Albendazole (Albenza)

Albendazole decreases ATP production in worms, causing energy depletion, immobilization, and, finally, death. To avoid inflammatory responses in the CNS, patients must also be started on anticonvulsants and high-dose glucocorticoids.


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