What is the role of spinosad in the treatment of pediculosis and pthiriasis (lice infestation)?

Updated: Aug 16, 2019
  • Author: Lyn C C Guenther, MD, FRCPC, FAAD; Chief Editor: Michael Stuart Bronze, MD  more...
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Spinosad 0.9% suspension (Natroba) was approved by the FDA in 2011 for the treatment of head louse infestation in patients aged 6 months and older. The product is applied to dry hair as a cream rinse, left in for 10 minutes, and then shampooed out. Spinosad is derived from the soil bacterium Saccharopolyspora spinosa. It has ovicidal activity. Retreatment is necessary only if live (ie, crawling) lice are seen one week after the first treatment. A phase 3 study showed that spinosad was more efficacious in clearing head lice than permethrin (P< 0.001). [34]

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